Case Based - Overview
Treatment Options for Triple-Negative Metastatic Breast Cancer
Release Date: July 30, 2008
Expiration Date: July 30, 2009
Interactive Case Study Overview
Approximately 15% of breast cancers are estrogen receptor–negative (ER–)/progesterone receptor–negative (PgR–)/HER2– (“triple-negative”) breast cancers. Triple-negative status is associated with increased aggressiveness and decreased recurrence-free survival. Since these tumors are not sensitive to hormonal or HER2-targeted therapy, therapeutic options for these patients have primarily consisted of systemic chemotherapy, while searches for novel targets continue. Although some chemotherapeutic regimens have demonstrated activity in patients with triple-negative breast cancer, there is no current standard of care for those patients. The aggressiveness of this tumor subtype requires that physicians stay informed of the efficacy and safety of therapeutic options for metastatic disease, both in the first-line setting and beyond, including antiangiogenic therapy and novel microtubule-targeted agents.
The purpose of this activity is to update physicians on the utility of new treatment options for triple-negative metastatic breast cancer (MBC), including antiangiogenic therapy and novel microtubule-targeted agents.
Target Audience
This educational activity is intended for medical oncologists involved in the care of patients with breast cancer. No specific skills or knowledge other than a basic training in oncology is required for successful participation in this activity.
Learning Objectives
Upon completion of this educational activity, you should be able to:
- Evaluate the utility of taxane and antiangiogenic agent combinations in patients with MBC
- Assess the efficacy of cytotoxic treatment options for patients with ER–/PgR–/HER2– MBC pretreated with anthracyclines and taxanes
- Summarize the toxicity profiles associated with epothilone-based therapy in patients with breast cancer
Instructions for Participation
- Read the following information before beginning the educational activity.
- Study the educational activity.
- Complete the CME test.
- Answer the evaluation questions.
- After successful completion of the CME test and evaluation, you will receive your certificate of credit online.
Successful completion is determined by a score of 67% or greater.
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