Case Based - Overview
Clinical Management of a Patient With a Localized Gastrointestinal Stromal Tumor
Release Date: April 14, 2009
Expiration Date: April 14, 2010
Interactive Case Study Overview
Insight into the molecular basis of gastrointestinal stromal tumor (GIST) growth has greatly changed the therapeutic landscape and the resulting outcomes of patients with this disease. Tyrosine kinase inhibitors (TKIs) targeting the main mutant receptors that drive tumor progression have improved progression-free and overall survival considerably in patients with advanced GIST. The majority of patients present with localized GIST, which can be treated with surgical resection; however, approximately half of these patients experience disease recurrence. Thus, recent clinical trials have evaluated the efficacy and safety of TKIs in both the neoadjuvant and adjuvant settings in patients with resectable GIST in order to reduce recurrence and improve outcomes. Ongoing investigations are focused on 3 major issues regarding the adjuvant treatment of patients with GIST: which patients will benefit from adjuvant therapy, how long therapy should be given, and the appropriate treatment course for patients with progressive disease following adjuvant therapy.
The purpose of this activity is to educate physicians about the available therapeutic options for treating patients with resectable GIST based on disease characteristics and recent evidence from relevant clinical trials.
This educational activity is intended for medical oncologists involved in the care of patients with GISTs. No specific skills or knowledge other than a basic training in oncology is required for successful participation in this activity.
Target Audience
Upon completion of this educational activity, you should be able to:
- Integrate current prognostic factor assessment into the selection of treatment for patients presenting with localized GIST
- Select appropriate patients for adjuvant therapy based on data from randomized clinical trials investigating the efficacy and safety of TKIs in resectable GIST
- Assess the therapeutic options for disease recurrence in patients who have received adjuvant therapy for localized GIST
Instructions for Participation
- Read the following information before entering the educational activity.
- Complete the Pretest.
- Study the educational activity.
- Complete the Posttest.
- Answer the evaluation questions.
- After completion of the Pretest and successful completion of the Posttest and evaluation, you will receive your certificate online.
You will be permitted 2 attempts to successfully complete the Posttest.
You will be asked to login
or create an account.