Lecture Details - Overview
E-Lert: Updates on Therapeutic Options for Breast Cancer - Targeted Agents
Release Date: December 3, 2009|
Expiration Date: December 3, 2010
0.5 AMA PRA Category 1 Credit(s)™|
Dec 3, 2009, E-Lert
Upon completion of this educational activity, you should be able to:
- Assess recent data regarding the safety and efficacy of inhibitors of PARP in patients with advanced breast cancer
- Evaluate recent data concerning the efficacy of antiangiogenic therapy combined with various cytotoxic agents for the treatment of MBC
- Discuss recent advances regarding the efficacy and safety of HER2-targeted therapy beyond progression on standard therapies for HER2+ advanced breast cancer
Overview and Purpose
Recent data on the treatment of breast cancer reflect a focus on targeted therapies. The novel approach of inhibiting poly(ADP-ribose) polymerase (PARP) in tumors with defective BRCA1/2 signaling might be particularly effective in triple-negative disease, for which no targeted approach is available. Studies are also examining the optimal chemotherapeutic partners for antiangiogenic therapy in metastatic breast cancer (MBC). In HER2+ disease, the role of focal HER2-amplified clones in the interpretation of HER2 testing and benefit from therapy is under investigation. Lastly, HER2-targeted antibody-drug conjugates and novel small-molecule tyrosine kinase inhibitors are demonstrating activity in patients with disease progression on standard HER2-targeted therapy, potentially increasing therapeutic options beyond progression.
The purpose of this activity is to update physicians on the latest clinically relevant data on targeted therapies in the treatment of breast cancer.
This educational activity is intended for medical oncologists involved in the care of patients with breast cancer. No specific skills or knowledge other than a basic training in oncology is required for successful participation in this activity.
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