Article Details - Overview
Oncology Briefings Vol. 6, No. 8
Release Date: November 25, 2008
Expiration Date: November 25, 2009
Publication Overview
Authors
Medical writer:
Timothy Quill, PhD; Reviewed by:
Nancy Dawson, MD, FACP
Overview and Purpose
Prostate cancer is the most commonly diagnosed cancer in men. In 2008, it is estimated that > 186,000 men in the United States will be diagnosed with prostate cancer, and that > 28,000 will die from this disease. Androgen deprivation therapy is an important element in the control of advanced prostate cancer; however, eventually all patients develop hormone-refractory prostate cancer (HRPC). The current standard of care for these patients is a docetaxel-based regimen. However, the moderate survival increase obtained with these regimens is balanced against an increased toxicity profile. Recently, an increased understanding of the molecular characteristics of prostate tumor cells and their propensity to metastasize to bone has led to the development of novel targeted approaches. Several clinical trials are currently evaluating these targeted agents in patients with HRPC.
The purpose of this activity is to apprise physicians of the rationale for and clinical data on endothelinA receptor antagonists in the treatment of patients with HRPC.
Target Audience
This activity is intended for medical oncologists involved in the care of patients with prostate cancer. No specific skills or knowledge other than a basic training in oncology is required for successful participation in this activity.
Learning Objectives
Upon completion of this educational activity, you should be able to:
- Review the importance of the endothelin axis in the development of bony disease in patients with prostate cancer
- Evaluate the efficacy of cytotoxic and targeted agents in the treatment of HRPC
- Assess the safety profile of cytotoxic and targeted agents in the treatment of HRPC
Instructions for Participation
- Read the following information before entering the educational activity.
- Complete the Pretest.
- Study the educational activity.
- Complete the CME test.
- Answer the evaluation questions.
- After successful completion of the CME test and evaluation, you will receive your certificate of credit online.
CME credit will be granted for only 1 form of participation, either online or via the printed publication.
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